Doramectin is a broad-spectrum macrocyclic lactone parasiticide used in veterinary medicine, primarily to treat and control internal (gastrointestinal roundworms, lungworms, eyeworms) and external (lice, mange mites, grubs) parasites in cattle and swine. 

Key Details & Uses

Mechanism: It paralyzes and kills parasites by binding to specific nerve and muscle cell receptors, altering chloride ion channels in the parasite's nervous system. 
Not for Humans: Doramectin is explicitly for veterinary use only and can cause severe neurological distress in humans if misused.
Administration & Dosage

Cattle: Administered at a dose of 1 mL per 110 lbs. of body weight, typically via subcutaneous (preferred) or intramuscular injection. Also available as a pour-on solution.

Swine: Administered at a dose of 1 mL per 75 lbs. of body weight via intramuscular injection only.

Withdrawal Periods & Safety

Cattle Meat Withdrawal: There is a strict 35-day withdrawal period required before treated cattle can be slaughtered for human consumption.

Dairy Restrictions: Not permitted for use in female dairy cattle 20 months of age or older to avoid drug residue in milk.

Veal Restrictions: Doramectin is not approved for use in calves intended to be processed for veal. [1]

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